Research progress on the biomedical application of microalgae

Microalgae is an easy-to-obtain natural biological material with many varieties and abundant natural reserves. Microalgae are rich in natural fluorescein, which can be used as a contrast agent for fluorescence imaging and photoacoustic imaging for medical imaging. With its active surface, microalgae can effectively adsorb functional molecules, metal elements, etc., and have good application prospects in the field of drug delivery. Microalgae can generate oxygen through photosynthesis to increase local oxygen concentration, reverse local hypoxia to enhance the efficacy of hypoxic tumors and promote wound healing. In addition, microalgae have good biocompatibility, and different administration methods have no obvious toxicity. This paper reviews the research progress on the biomedical application of microalgae in bioimaging, drug delivery, hypoxic tumor treatment, wound healing.

Keywords: Bioimaging; Drug delivery; Hypoxic tumor therapy; Microalgae; Review; Wound healing.

Conflict of interest statement

Similar articles

Zhong D, Li W, Hua S, Qi Y, Xie T, Qiao Y, Zhou M. Zhong D, et al. Theranostics. 2021 Jan 22;11(8):3580-3594. doi: 10.7150/thno.55441. eCollection 2021. Theranostics. 2021. PMID: 33664849 Free PMC article.

Qiao Y, Yang F, Xie T, Du Z, Zhong D, Qi Y, Li Y, Li W, Lu Z, Rao J, Sun Y, Zhou M. Qiao Y, et al. Sci Adv. 2020 May 20;6(21):eaba5996. doi: 10.1126/sciadv.aba5996. eCollection 2020 May. Sci Adv. 2020. PMID: 32490207 Free PMC article.

Zhang C, Han ZY, Chen KW, Wang YZ, Bao P, Ji P, Yan X, Rao ZY, Zeng X, Zhang XZ. Zhang C, et al. Nano Lett. 2024 Mar 27;24(12):3801-3810. doi: 10.1021/acs.nanolett.4c00471. Epub 2024 Mar 13. Nano Lett. 2024. PMID: 38477714

Zhang T, Liu D, Zhang Y, Chen L, Zhang W, Sun T. Zhang T, et al. Mater Today Bio. 2024 Jul 14;27:101154. doi: 10.1016/j.mtbio.2024.101154. eCollection 2024 Aug. Mater Today Bio. 2024. PMID: 39113912 Free PMC article. Review.

Cui H, Su Y, Wei W, Xu F, Gao J, Zhang W. Cui H, et al. Int J Nanomedicine. 2022 Jul 15;17:3101-3122. doi: 10.2147/IJN.S368763. eCollection 2022. Int J Nanomedicine. 2022. PMID: 35874112 Free PMC article. Review.

References

    1. IGE O O, UMORU L E, ARIBO S. Natural products: a minefield of biomaterials[J] ISRN Mater Sci. . 2012;2012:1–20. doi: 10.5402/2012/983062. - DOI
    1. GANGL D, ZEDLER J A Z, RAJAKUMAR P D, et al. Biotechnological exploitation of microalgae[J] J Exp Bot. . 2015;66(22):6975–6990. doi: 10.1093/jxb/erv426. - DOI - PubMed
    1. TORRES-TIJI Y, FIELDS F J, MAYFIELD S P. Microalgae as a future food source[J] Biotechnol Adv. . 2020;41:107536. doi: 10.1016/j.biotechadv.2020.107536. - DOI - PubMed
    1. BHUJADE R, CHIDAMBARAM M, KUMAR A, et al. Algae to economically viable low-carbon-footprint oil[J] Annu Rev Chem Biomol Eng. . 2017;8(1):335–357. doi: 10.1146/annurev-chembioeng-060816-101630. - DOI - PubMed
    1. MONTERO L, DEL PILAR SÁNCHEZ-CAMARGO A, IBÁÑEZ E, et al. Phenolic compounds from edible algae: bioactivity and health benefits[J] Curr Med Chem. . 2018;25(37):4808–4826. doi: 10.2174/0929867324666170523120101. - DOI - PubMed